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Concise Prescribing Info
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Daclatasvir
Indications / Uses
In combination w/ other medicines for chronic hepatitis C in adults.
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Dosage / Direction for Use
60 mg once daily. Co-administered w/ strong CYP3A4 inhibitors 30 mg once daily. Co-administered w/ moderate CYP3A4 inducers 90 mg once daily.
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Overdosage
View Daclavir overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Co-administration w/ strong CYP3A4 & P-gp inducers eg, phenytoin, carbamazepine, oxcarbazepine, phenobarb, rifampicin, rifabutin, rifapentine, systemic dexamethasone, St. John's wort.
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Special Precautions
Not to be given as monotherapy. Severe bradycardia & heart block. Patients w/ genotype 4 & 6 HCV infection; HBV/HCV co-infection; prior exposure to NS5A inhibitor. Perform HBV screening prior to treatment. Concomitant use w/ amiodarone. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Women of childbearing potential should use effective contraception for 5 wk after completion of therapy. Not to be used during pregnancy & lactation. Not recommended in childn & adolescents <18 yr.
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Side Effects / Adverse Reactions
Anaemia; headache; nausea; fatigue. Decreased appetite; insomnia, irritability; dizziness, migraine; hot flush; dyspnoea, exertional dyspnoea, cough, nasal congestion; diarrhoea, vomiting, abdominal pain, GERD, constipation, dry mouth, flatulence; rash, alopecia, pruritus, dry skin; arthralgia, myalgia.
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Interactions
Increased conc w/ boceprevir, simeprevir, telaprevir, atazanavir/ritonavir, dolutegravir, elvitegravir, cobicistat, emtricitabine, tenofovir disoproxil fumarate, clarithromycin, telithromycin, erythromycin, dabigatran etexilate, antifungals, digoxin, Ca-channel blockers, HMG-CoA reductase inhibitors, narcotic analgesics. Decreased conc w/ efavirenz, etravirine, nevirapine, carbamazepine, oxcarbazepine, phenobarb, phenytoin, rifampicin, rifabutin, rifapentine, systemic dexamethasone, St. John's wort.
Caution For Usage
For caution against possible variation of physical aspect of medicine... click to view detailed Daclavir Caution For Usage
Storage
View Daclavir storage conditions for details to ensure optimal shelf-life.
Description
View Daclavir description for details of the chemical structure and excipients (inactive components).
Mechanism of Action
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ATC Classification
J05AP07 - daclatasvir ; Belongs to the class of antivirals for treatment of HCV infections. Used in the treatment of hepatitis C viral infections.
Presentation / Packing
FormPacking/Price
Daclavir FC tab 60 mg
28's



ck棋牌Daclavir6002316CL_4c.GIF

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